A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Epidemiology of Guillain-Barré syndrome in Finland 2004–2014
Tekijät: Jussi O.T. Sipilä, Merja Soilu‐Hänninen, Jori O. Ruuskanen, Päivi Rautava, Ville Kytö
Kustantaja: WILEY
Julkaisuvuosi: 2017
Journal: Journal of the Peripheral Nervous System
Tietokannassa oleva lehden nimi: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
Lehden akronyymi: J PERIPHER NERV SYST
Vuosikerta: 22
Numero: 4
Aloitussivu: 440
Lopetussivu: 445
Sivujen määrä: 6
ISSN: 1085-9489
DOI: https://doi.org/10.1111/jns.12239
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/28324023
At total mean incidence of 0.84-1.1/100,000 the occurrence of Guillain-Barre syndrome (GBS) is reported to be low in Finland compared to other Caucasian populations. However, a recent study from Southwestern Finland reported an incidence of 1.82/100,000 which is comparable to other Caucasian populations. We analyzed discharge data covering the years 2004 through 2014 on all neurological admissions in all Finnish university and central hospitals with a primary diagnosis of GBS. A total of 989 admissions due to GBS (917 individuals) were identified. The standardized (European population) annual incidence rate was 1.70/100,000 person-years (95% confidence interval 1.60-1.81). GBS incidence had an increasing trend with age. The likelihood of GBS was higher among girls and adolescent women than boys and men of same age (male:female incidence rate ratio [IRR] 0.56), while in the older age groups (>19years) the occurrence of GBS was higher among males than females (male:female IRR 1.59). The incidence of GBS remained stable during the study period. There was no seasonal variation in GBS admission frequencies (p=0.28). No significant effect of the 2009-2010 H1N1 influenza or vaccination against it for GBS occurrence was observed. We suggest that GBS is as common, and has similar age-distribution in Finland as in other European countries. Sex-associated susceptibility for GBS appears to be different in children-adolescents and adults.
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