A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer
Tekijät: Hilker C., Windebank S., Meyer J., Zuber V., Mills I., Andreassen O., Witoelar A., Bettella F., Kote-Jarai Z., Easton D., Eeles R., Urbanucci A., Giles G., Muir K., Benlloch S., Al Olama A., Weischer M., Travis R., Neal D., Pharoah P., Wiklund F., Gronberg H., Haiman C., Schleutker J., Maier C., Kibel A., Cybulski C., Cannon-Albright L., Khaw K., Stanford J., Blot W., Thibodeau S., Pandha H., Teixeira M., Humphreys M., Chenevix-Trench G., Park J., Brenner H., Batra J., Kaneva R., Houlston R., Rosenberger A., Landi M., Caporaso N., Han Y., Hung R., Bickeböller H., Brennan P., Easton D., Michailidou K., Christiani D., Amos C., Wu X., Ye Y., Heinrich J., Risch A., Offit K., Dennis J., McGuffog L., Couch F., Berchuck A., Antoniou A., Bolla M., Wang Q., Tessier D., Simard J., Gonzalez-Neira A., Benitez J., Luccarini C., Dicks E., Lee A., Dunning A., Cunningham J., Nordestgaard B., Nielsen S., Bojesen S., Robidoux F., LaBoissière S., Vincent D., Bacot F.
Kustantaja: BioMed Central Ltd.
Julkaisuvuosi: 2017
Journal: BMC Genomics
Tietokannassa oleva lehden nimi: BMC Genomics
Vuosikerta: 18
Numero: 1
Sivujen määrä: 11
ISSN: 1471-2164
DOI: https://doi.org/10.1186/s12864-017-3620-y
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/28257379
Conclusions
This is the first study to evaluate the enrichment of epigenetic readers in genome-wide associations studies for SNPs within enhancers, and provides a powerful tool for enriching and prioritizing PC and BC genetic risk loci. Our study represents a proof of principle applicable to other diseases and traits that can be used to redefine molecular mechanisms of human phenotypic variation.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
