A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa
Microbial Composition of the Initial Colonization of Newborns
Tekijät: Rautava Samuli
Toimittaja: Isolauri E., Sherman P.M., Walker W.A.
Konferenssin vakiintunut nimi: Nestle Nutrition Institute Workshop
Kustantaja: S KARGER AG, MR. THOMAS KARGER, CH-4009 BASEL, SWITZERLAND
Kustannuspaikka: Basel
Julkaisuvuosi: 2017
Kokoomateoksen nimi: Intestinal Microbiome: Functional Aspects in Health and Disease. 88th Nestlé Nutrition Institute Workshop, Playa del Carmen, September 2016
Tietokannassa oleva lehden nimi: INTESTINAL MICROBIOME: FUNCTIONAL ASPECTS IN HEALTH AND DISEASE
Lehden akronyymi: NESTLE NUTR WORKS SE
Sarjan nimi: Nestle Nutrition Institute Workshop Series
Vuosikerta: 88
Aloitussivu: 11
Lopetussivu: 21
Sivujen määrä: 11
ISBN: 978-3-318-06030-0
eISBN: 978-3-318-06031-7
ISSN: 1664-2147
DOI: https://doi.org/10.1159/000455209
Verkko-osoite: https://www.karger.com/Article/FullText/455209
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/28137946
Early-life interaction with indigenous intestinal microbes is a prerequisite for healthy immune and metabolic maturation. Human infants acquire their gut microbiota predominantly from the mother. A considerable inoculum of microbes is received by the neonate during vaginal delivery. Recent observations suggest that human gut colonization may be initiated prenatally by microbes in amniotic fluid, but the significance of this phenomenon remains unknown. After birth, neonatal gut colonization is guided by human milk factors, which selectively promote the growth of specific microbes, as well as by live microbes present in human milk. Aberrant gut colonization in early life has been associated with an increased risk of noncommunicable diseases in later life. Epidemiological and experimental studies suggest a causal relationship between early-life gut microbiota perturbations and disease risk. Perinatal antibiotic exposure, cesarean section delivery, postnatal antibiotic administration, and formula feeding, which may disrupt intestinal microecology, have been associated with disease development in later life. The modulation of gut microbiota in the perinatal period by pre- and probiotics, for example, may offer a means to reduce the risk of chronic diseases. (C) 2017 Nestec Ltd., Vevey/S. Karger AG, Basel
Ladattava julkaisu This is an electronic reprint of the original article. |  |
