α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction - UTU Research Portal

A1 Refereed original research article in a scientific journal

α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction

Authors: Petteri Rinne, Wendy Nordlund, Ilkka Heinonen, Anna-Maija Penttinen, Antti Saraste, Suvi T. Ruohonen, Satu Mäkelä, Laura Vähätalo, Katja Kaipio, Minying Cai, Victor J. Hruby, Saku Ruohonen, Eriika Savontaus

Publisher: OXFORD UNIV PRESS

Publication year: 2013

Journal: Cardiovascular Research

Journal name in source: CARDIOVASCULAR RESEARCH

Journal acronym: Cardiovasc Res

Number in series: 2

Volume: 97

Issue: 2

First page : 360

Last page: 368

Number of pages: 9

ISSN: 0008-6363

eISSN: 1755-3245

DOI: https://doi.org/10.1093/cvr/cvs335(external)

Abstract

The present study identifies -MSH and endothelial MC1 receptors as a new signalling pathway contributing to the regulation of NO availability and vascular function. These findings suggest applicability of -MSH analogues for therapeutic use in pathological conditions that are characterized by vascular dysfunction.