A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs
Tekijät: Yahya M, Rulli M, Toivonen L, Waris M, Peltola V
Kustantaja: OXFORD UNIV PRESS INC
Julkaisuvuosi: 2017
Journal: Journal of Infectious Diseases
Tietokannassa oleva lehden nimi: JOURNAL OF INFECTIOUS DISEASES
Lehden akronyymi: J INFECT DIS
Vuosikerta: 216
Numero: 9
Aloitussivu: 1099
Lopetussivu: 1103
Sivujen määrä: 5
ISSN: 0022-1899
DOI: https://doi.org/10.1093/infdis/jix458
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/27882743
Respiratory viruses frequently cause symptomatic infections in children but are often detected also in healthy children. We investigated myxovirus resistance protein A (MxA), viperin, and tripartite-motif 21 (TRIM21) messenger RNA indexes in nasal swabs as potential biomarkers of viral respiratory infection in children. Respiratory viruses were detected by polymerase chain reaction in the same swabs. Nasal MxA and viperin indexes were increased in symptomatic virus-positive children. Nasal viperin index was found to be a robust marker of viral respiratory tract infection with a sensitivity of 80% and specificity of 94% in distinguishing children with symptomatic virus infections from asymptomatic virus-negative children.
Ladattava julkaisu This is an electronic reprint of the original article. |  | |
Ladattava julkaisu This is an electronic reprint of the original article. | |
