A1 Refereed original research article in a scientific journal
Early Nutrition and Growth until the Corrected Age of 2 Years in Extremely Preterm Infants
Authors: Hiltunen H, Löyttyniemi E, Isolauri E, Rautava S.
Publication year: 2018
Journal: Neonatology
Volume: 113
Issue: 2
First page : 100
Last page: 107
Number of pages: 8
ISSN: 1661-7800
DOI: https://doi.org/10.1159/000480633
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/27875057
AbstractBACKGROUND:
Extremely preterm birth is associated with a high risk of extrauterine growth retardation, which has been linked with adverse developmental outcomes.
OBJECTIVE:We investigated whether nutritional management during the first 7 days of life affects growth patterns until the corrected age of 2 years in extremely preterm infants.
STUDY DESIGN:A retrospective study of 78 extremely preterm (<28 weeks' gestation) neonates was conducted. Data regarding parenteral and enteral intake of energy, protein, lipids, and carbohydrates during the first 7 days of life were collected from patient records. The outcome measures included weight, height, and head circumference with Z scores at term-equivalent age and the corrected ages of 1 and 2 years. Analyses were performed with hierarchical-linear mixed models.
RESULTS:Nutritional intake during the first week of life did not reach the current recommendations. The total energy intake during the first 7 days of life was statistically significantly associated with weight, length, and head circumference until the corrected age of 2 years after adjusting for potential confounding factors. Individual macronutrient intake displayed no association with growth patterns.
CONCLUSIONS:Energy intake during the first 7 days of life is associated with growth until the corrected age of 2 years. These results provide support for the aggressive early nutritional management of extremely preterm infants.
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