S-ketamine concentrations are greatly increased by grapefruit juice



: Peltoniemi MA, Saari TI, Hagelberg NM, Laine K, Neuvonen PJ, Olkkola KT

Publisher: SPRINGER HEIDELBERG

: 2012

 European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 6

: 68

: 6

: 979

: 986

: 8

: 0031-6970

DOI: https://doi.org/10.1007/s00228-012-1214-9


Grapefruit juice significantly increased the plasma concentrations of oral ketamine in healthy volunteers. Dose reductions of ketamine should be considered when using oral ketamine concomitantly with grapefruit juice.


Analgesics, Citrus paradisi (grapefruit juice), Cytochrome P450 CYP3A, Drug interaction, Ketamine, Oral administration



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