A1 Refereed original research article in a scientific journal

S-ketamine concentrations are greatly increased by grapefruit juice



Authors: Peltoniemi MA, Saari TI, Hagelberg NM, Laine K, Neuvonen PJ, Olkkola KT

Publisher: SPRINGER HEIDELBERG

Publication year: 2012

Journal: European Journal of Clinical Pharmacology

Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: EUR J CLIN PHARMACOL

Number in series: 6

Volume: 68

Issue: 6

First page : 979

Last page: 986

Number of pages: 8

ISSN: 0031-6970

DOI: https://doi.org/10.1007/s00228-012-1214-9


Abstract
Grapefruit juice significantly increased the plasma concentrations of oral ketamine in healthy volunteers. Dose reductions of ketamine should be considered when using oral ketamine concomitantly with grapefruit juice.


Keywords:
Analgesics, Citrus paradisi (grapefruit juice), Cytochrome P450 CYP3A, Drug interaction, Ketamine, Oral administration



Last updated on 26/11/2024 05:59:46 PM