Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly
: Pakkanen SH, Kantele JM, Savolainen LE, Rombo L, Kantele A
Publisher: ELSEVIER SCI LTD
: 2015
: Vaccine
: VACCINE
: VACCINE
: 33
: 3
: 451
: 458
: 8
: 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2014.11.030
Conclusions: Concomitant administration of Ty21a and Vi vaccines is well tolerated and induces an additive immune response to the two vaccines. Thus it enhances the magnitude of both typhoid-specific plasmablast responses and those cross-reacting with paratyphoid and most important NTS serotypes. The data encourage concomitant use of Ty21 and Vi vaccines for those at risk. (C) 2014 The Authors. Published by Elsevier Ltd.
