Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly - UTU Research Portal

A1 Refereed original research article in a scientific journal

Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly

Authors: Pakkanen SH, Kantele JM, Savolainen LE, Rombo L, Kantele A

Publisher: ELSEVIER SCI LTD

Publication year: 2015

Journal: Vaccine

Journal name in source: VACCINE

Journal acronym: VACCINE

Volume: 33

Issue: 3

First page : 451

Last page: 458

Number of pages: 8

ISSN: 0264-410X

DOI: https://doi.org/10.1016/j.vaccine.2014.11.030

Abstract

Conclusions: Concomitant administration of Ty21a and Vi vaccines is well tolerated and induces an additive immune response to the two vaccines. Thus it enhances the magnitude of both typhoid-specific plasmablast responses and those cross-reacting with paratyphoid and most important NTS serotypes. The data encourage concomitant use of Ty21 and Vi vaccines for those at risk. (C) 2014 The Authors. Published by Elsevier Ltd.

Keywords:

Antibody-secreting cell, Cross-reactive, ELISPOT, HomingClinicalTrials.gov NCT02121145, Non-typhoid Salmonella, Paratyphoid fever, Salmonella gastroenteritis, Salmonella Typhi, Salmonella Typhi Ty21a, S. Paratyphi, Typherix, Typhim Vi, Typhoid fever, Vi polysaccharide, Vivotif