Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly - UTU Research Portal

A1 Refereed original research article in a scientific journal

Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly

Authors: Pakkanen SH, Kantele JM, Savolainen LE, Rombo L, Kantele A

Publisher: ELSEVIER SCI LTD

Publication year: 2015

Journal: Vaccine

Journal name in source: VACCINE

Journal acronym: VACCINE

Volume: 33

Issue: 3

First page : 451

Last page: 458

Number of pages: 8

ISSN: 0264-410X

DOI: https://doi.org/10.1016/j.vaccine.2014.11.030

Abstract

Conclusions: Concomitant administration of Ty21a and Vi vaccines is well tolerated and induces an additive immune response to the two vaccines. Thus it enhances the magnitude of both typhoid-specific plasmablast responses and those cross-reacting with paratyphoid and most important NTS serotypes. The data encourage concomitant use of Ty21 and Vi vaccines for those at risk. (C) 2014 The Authors. Published by Elsevier Ltd.