A1 Refereed original research article in a scientific journal
PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival
Authors: Repo H, Gurvits N, Loyttyniemi E, Nykanen M, Lintunen M, Karra H, Kurki S, Kuopio T, Talvinen K, Soderstrom M, Kronqvist P
Publisher: BIOMED CENTRAL LTD
Publication year: 2017
Journal: BMC Cancer
Journal name in source: BMC CANCER
Journal acronym: BMC CANCER
Article number: ARTN 705
Volume: 17
Number of pages: 8
ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-017-3694-6
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/27375005
Background: PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin from the cell cytoplasm to the nucleus, allowing the interaction between separase and securin. PTTG1IP overexpression has been previously observed in malignant disease, e.g. in breast carcinoma. However, the prognostic value of PTTG1IP in breast carcinoma patients has not previously been revealed.Methods: A total of 497 breast carcinoma patients with up to 22-year follow-up were analysed for PTTG1IP and securin immunoexpression. The results were evaluated for correlations with the clinical prognosticators and patient survival.Results: In our material, negative PTTG1IP immunoexpression predicted a 1.5-fold risk of breast cancer death (p = 0.02). However, adding securin immunoexpression to the analysis indicated an even stronger and independent prognostic power in the patient material (HR = 2.5, p < 0.0001). The subcellular location of securin was found with potential prognostic value also among the triple-negative breast carcinomas (n = 96, p = 0.052).Conclusions: PTTG1IP-negativity alone and in combination with high securin immunoexpression indicates a high risk of breast cancer death, resulting in up to 14-year survival difference in our material.
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