Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer



: Cook KL, Warri A, Soto-Pantoja DR, Clarke PAG, Cruz MI, Zwart A, Clarke R

Publisher: AMER ASSOC CANCER RESEARCH

: 2014

: Clinical Cancer Research

: CLINICAL CANCER RESEARCH

: CLIN CANCER RES

: 20

: 12

: 3222

: 3232

: 11

: 1078-0432

: 1557-3265

DOI: https://doi.org/10.1158/1078-0432.CCR-13-3227(external)


Conclusion: HCQ restores antiestrogen sensitivity to resistant tumors. Moreover, the beneficial combination of TAM+HCQ suggests a positive outcome for ongoing neoadjuvant clinical trials using this combination for the treatment of ER+ ductal carcinoma in situ lesions. (C) 2014 AACR.




Last updated on 2024-26-11 at 15:44