Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer - UTU Research Portal

A1 Refereed original research article in a scientific journal

Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

Authors: Cook KL, Warri A, Soto-Pantoja DR, Clarke PAG, Cruz MI, Zwart A, Clarke R

Publisher: AMER ASSOC CANCER RESEARCH

Publication year: 2014

Journal: Clinical Cancer Research

Journal name in source: CLINICAL CANCER RESEARCH

Journal acronym: CLIN CANCER RES

Volume: 20

Issue: 12

First page : 3222

Last page: 3232

Number of pages: 11

ISSN: 1078-0432

eISSN: 1557-3265

DOI: https://doi.org/10.1158/1078-0432.CCR-13-3227(external)

Abstract

Conclusion: HCQ restores antiestrogen sensitivity to resistant tumors. Moreover, the beneficial combination of TAM+HCQ suggests a positive outcome for ongoing neoadjuvant clinical trials using this combination for the treatment of ER+ ductal carcinoma in situ lesions. (C) 2014 AACR.