Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette-Guerin vaccination

: Liehu-Martiskainen M, Korppi M, Teräsjärvi J, Vuononvirta J, Huhtala H, Nuolivirta K, Kroger L, Peltola V, Poyhonen L, He QS

Publisher: WILEY

: 2017

: Acta Paediatrica

: ACTA PAEDIATRICA

: ACTA PAEDIATR

: 106

: 11

: 1837

: 1841

: 5

: 0803-5253

: 1651-2227

DOI: https://doi.org/10.1111/apa.14000

Aim: Interleukin-17 (IL-17) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between IL17A gene polymorphism and the risk of Bacillus Calmette-Guerin (BCG) osteitis after newborn vaccination and between IL17A gene polymorphism and IL-17A concentrations in serum.Methods: IL17A rs2275913 gene polymorphisms and serum IL-17A concentrations were studied in 132 adults aged 21-49 years from across Finland, who had BCG osteitis in infancy after a newborn BCG vaccination. The subjects were recruited in 2007-2008, and their whole-blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population-based unvaccinated controls aged two to three months from a prospective birth cohort study.Results: The genotypes and allele frequencies of IL17A rs2275913 differed significantly between the former BCG osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum IL-17 concentrations did not differ significantly between the cases with wild or variant genotypes.Conclusion: IL17A rs2275913 gene polymorphism was associated with a risk of BCG osteitis after vaccination.