A1 Refereed original research article in a scientific journal
Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette-Guerin vaccination
Authors: Liehu-Martiskainen M, Korppi M, Teräsjärvi J, Vuononvirta J, Huhtala H, Nuolivirta K, Kroger L, Peltola V, Poyhonen L, He QS
Publisher: WILEY
Publication year: 2017
Journal: Acta Paediatrica
Journal name in source: ACTA PAEDIATRICA
Journal acronym: ACTA PAEDIATR
Volume: 106
Issue: 11
First page : 1837
Last page: 1841
Number of pages: 5
ISSN: 0803-5253
eISSN: 1651-2227
DOI: https://doi.org/10.1111/apa.14000
Abstract
Aim: Interleukin-17 (IL-17) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between IL17A gene polymorphism and the risk of Bacillus Calmette-Guerin (BCG) osteitis after newborn vaccination and between IL17A gene polymorphism and IL-17A concentrations in serum.Methods: IL17A rs2275913 gene polymorphisms and serum IL-17A concentrations were studied in 132 adults aged 21-49 years from across Finland, who had BCG osteitis in infancy after a newborn BCG vaccination. The subjects were recruited in 2007-2008, and their whole-blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population-based unvaccinated controls aged two to three months from a prospective birth cohort study.Results: The genotypes and allele frequencies of IL17A rs2275913 differed significantly between the former BCG osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum IL-17 concentrations did not differ significantly between the cases with wild or variant genotypes.Conclusion: IL17A rs2275913 gene polymorphism was associated with a risk of BCG osteitis after vaccination.
Aim: Interleukin-17 (IL-17) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between IL17A gene polymorphism and the risk of Bacillus Calmette-Guerin (BCG) osteitis after newborn vaccination and between IL17A gene polymorphism and IL-17A concentrations in serum.Methods: IL17A rs2275913 gene polymorphisms and serum IL-17A concentrations were studied in 132 adults aged 21-49 years from across Finland, who had BCG osteitis in infancy after a newborn BCG vaccination. The subjects were recruited in 2007-2008, and their whole-blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population-based unvaccinated controls aged two to three months from a prospective birth cohort study.Results: The genotypes and allele frequencies of IL17A rs2275913 differed significantly between the former BCG osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum IL-17 concentrations did not differ significantly between the cases with wild or variant genotypes.Conclusion: IL17A rs2275913 gene polymorphism was associated with a risk of BCG osteitis after vaccination.
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