A2 Refereed review article in a scientific journal
Cardiac Progenitor Cells and the Interplay with Their Microenvironment
Authors: Mauretti A, Spaans S, Bax NAM, Sahlgren C, Bouten CVC
Publisher: HINDAWI LTD
Publication year: 2017
Journal: Stem Cells International
Journal name in source: STEM CELLS INTERNATIONAL
Journal acronym: STEM CELLS INT
Article number: ARTN 7471582
Number of pages: 20
ISSN: 1687-966X
eISSN: 1687-9678
DOI: https://doi.org/10.1155/2017/7471582
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/27260198
Abstract
The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.
The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.
Downloadable publication This is an electronic reprint of the original article. |  |
UTU Research Portal