Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs

: Restitutti F., Kaartinen M., Raekallio M., Wejberg O., Mikkola E., del Castillo J., Scheinin M., Vainio O.

Publisher: Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia

: 2017

: Veterinary Anaesthesia and Analgesia

: 44

: 3

: 417

: 426

: 10

: 1467-2987

DOI: https://doi.org/10.1016/j.vaa.2016.04.006

Conclusions and clinical relevance

Initial haemodynamic effects of medetomidine were not prevented by MK-467, but these effects were attenuated and their duration shortened by MK-467, independently of dose. Absorption of medetomidine was accelerated by MK-467, when administered concomitantly IM, resulting in faster sedation; addition of MK-467 shortened the sedative effect of medetomidine.