Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs

Tekijät: Restitutti F., Kaartinen M., Raekallio M., Wejberg O., Mikkola E., del Castillo J., Scheinin M., Vainio O.

Kustantaja: Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia

Julkaisuvuosi: 2017

Journal: Veterinary Anaesthesia and Analgesia

Tietokannassa oleva lehden nimi: Veterinary Anaesthesia and Analgesia

Vuosikerta: 44

Numero: 3

Aloitussivu: 417

Lopetussivu: 426

Sivujen määrä: 10

ISSN: 1467-2987

DOI: https://doi.org/10.1016/j.vaa.2016.04.006

Tiivistelmä

Conclusions and clinical relevance

Initial haemodynamic effects of medetomidine were not prevented by MK-467, but these effects were attenuated and their duration shortened by MK-467, independently of dose. Absorption of medetomidine was accelerated by MK-467, when administered concomitantly IM, resulting in faster sedation; addition of MK-467 shortened the sedative effect of medetomidine.