A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Synthesis of Biotinylated Multipodal Glycoclusters on a Solid Support
Tekijät: Karskela M, von Usedom M, Virta P, Lonnberg H
Kustantaja: WILEY-V C H VERLAG GMBH
Julkaisuvuosi: 2012
Journal: European Journal of Organic Chemistry
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Lehden akronyymi: EUR J ORG CHEM
Numero sarjassa: 33
Vuosikerta: 2012
Numero: 33
Aloitussivu: 6594
Lopetussivu: 6605
Sivujen määrä: 12
ISSN: 1434-193X
DOI: https://doi.org/10.1002/ejoc.201200926
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/2721374
Trivalent glycoconjugates, each bearing a biotin side arm in addition to three different sugar ligands, have been synthesized on a solid support. The conjugates were assembled on an orthogonally protected pentaerythrityl tetramine core that was anchored to the support through a backbone amide linker. Peptide coupling chemistry was applied to elongate three of the branches with beta-alanine and a fully acylated glycosylacetic acid. The fourth branch was levulinoylated and oximated with aminooxy-derivatized D-biotin, followed by acidolytic release into solution. The acyl protecting groups were removed by methoxide-catalyzed transesterification in methanol.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
