B1 Non-refereed article in a scientific journal
Food allergy in a child with de novo KAT6A mutation
Authors: Elenius Varpu, Lähdesmäki Tuire, Hietala Marja, Jartti Tuomas
Publisher: BIOMED CENTRAL LTD
Publication year: 2017
Journal: Clinical and Translational Allergy
Journal name in source: CLINICAL AND TRANSLATIONAL ALLERGY
Journal acronym: CLIN TRANSL ALLERGY
Article number: 19
Volume: 7
Number of pages: 3
ISSN: 2045-7022
DOI: https://doi.org/10.1186/s13601-017-0155-x
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/27066755
Abstract
Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet. The present case does not establish proof of cause, but highlights the importance of careful clinical diagnostics despite other possible causes for feeding problems. Recognizing that early feeding problems these patients regularly have might be caused by food allergy is important for outcome and quality of life for these patients.
Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet. The present case does not establish proof of cause, but highlights the importance of careful clinical diagnostics despite other possible causes for feeding problems. Recognizing that early feeding problems these patients regularly have might be caused by food allergy is important for outcome and quality of life for these patients.
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