A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial
Tekijät: Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T
Kustantaja: American Medical Association
Julkaisuvuosi: 2016
Journal: JAMA: Journal of the American Medical Association
Vuosikerta: 315
Numero: 11
Aloitussivu: 1120
Lopetussivu: 1128
Sivujen määrä: 9
ISSN: 0098-7484
eISSN: 1538-3598
DOI: https://doi.org/10.1001/jama.2016.1933
Conclusions and Relevance Among comatose survivors of out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia compared with hypothermia alone resulted in less white matter damage as measured by fractional anisotropy of diffusion tensor MRI. However, there was no statistically significant difference in neurological outcomes or mortality at 6 months. These preliminary findings require further evaluation in an adequately powered clinical trial designed to assess clinical outcomes associated with inhaled xenon among survivors of out-of-hospital cardiac arrest.
