A1 Refereed original research article in a scientific journal

Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial




AuthorsLaitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T

PublisherAmerican Medical Association

Publication year2016

JournalJAMA: Journal of the American Medical Association

Volume315

Issue11

First page 1120

Last page1128

Number of pages9

ISSN0098-7484

eISSN1538-3598

DOIhttps://doi.org/10.1001/jama.2016.1933


Abstract

Conclusions and Relevance  Among comatose survivors of out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia compared with hypothermia alone resulted in less white matter damage as measured by fractional anisotropy of diffusion tensor MRI. However, there was no statistically significant difference in neurological outcomes or mortality at 6 months. These preliminary findings require further evaluation in an adequately powered clinical trial designed to assess clinical outcomes associated with inhaled xenon among survivors of out-of-hospital cardiac arrest.



Last updated on 2024-26-11 at 21:47