A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Decreased male reproductive success in association with mitochondrial dysfunction
Tekijät: Martikainen MH, Grady JP, Ng YS, Alston CL, Gorman GS, Taylor RW, McFarland R, Turnbull DM
Kustantaja: NATURE PUBLISHING GROUP
Kustannuspaikka: LONDON
Julkaisuvuosi: 2017
Journal: European Journal of Human Genetics
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF HUMAN GENETICS
Lehden akronyymi: EUR J HUM GENET
Vuosikerta: 25
Numero: 10
Aloitussivu: 1162
Lopetussivu: 1164
Sivujen määrä: 3
ISSN: 1018-4813
eISSN: 1476-5438
DOI: https://doi.org/10.1038/ejhg.2017.114
Verkko-osoite: 10.1038/ejhg.2017.114
Tiivistelmä
The reproductive success of men with mitochondrial disease is to date unreported. We compared the age- and era-adjusted reproductive success of 94 British male patients with mitochondrial disease to that of the UK general male population. The reproductive success of men with mitochondrial disease was 65% of that in the general population (95% confidence interval: 53%; 79%), and the effect magnitude was related to the disease severity. This contrasts with the two previous studies finding that the reproductive success of women with mitochondrial DNA disease is not impaired. We conclude that the reproductive health of men with mitochondrial disease merits increased clinical attention.
The reproductive success of men with mitochondrial disease is to date unreported. We compared the age- and era-adjusted reproductive success of 94 British male patients with mitochondrial disease to that of the UK general male population. The reproductive success of men with mitochondrial disease was 65% of that in the general population (95% confidence interval: 53%; 79%), and the effect magnitude was related to the disease severity. This contrasts with the two previous studies finding that the reproductive success of women with mitochondrial DNA disease is not impaired. We conclude that the reproductive health of men with mitochondrial disease merits increased clinical attention.
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