A1 Refereed original research article in a scientific journal
Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort
Authors: Mogensen SS, Harila-Saari A, Frandsen TL, Lahteenmaki P, Castor A, Kohonen I, Schmiegelow K, Makitie O
Publisher: WILEY
Publication year: 2017
Journal: Pediatric Blood and Cancer
Journal name in source: PEDIATRIC BLOOD & CANCER
Journal acronym: PEDIATR BLOOD CANCER
Article number: ARTN e26624
Volume: 64
Issue: 11
Number of pages: 4
ISSN: 1545-5009
eISSN: 1545-5017
DOI: https://doi.org/10.1002/pbc.26624
Abstract
Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.
Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.
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