A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function
Tekijät: Koivunen JT, Nissinen L, Kapyla J, Jokinen J, Pihlavisto M, Marjamaki A, Heino J, Huuskonen J, Pentikainen OT
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2011
Lehti: Journal of the American Chemical Society
Tietokannassa oleva lehden nimi: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Lehden akronyymi: J AM CHEM SOC
Numero sarjassa: 37
Vuosikerta: 133
Numero: 37
Aloitussivu: 14558
Lopetussivu: 14561
Sivujen määrä: 4
ISSN: 0002-7863
DOI: https://doi.org/10.1021/ja206086c
Tiivistelmä
Collagen binding integrins are an important family of cell surface receptors that mediate bidirectionally signals between the interior of the cell and the extracellular matrix. The protein-protein interactions between cells and collagen are necessary for many physiological functions, but also promote diseases. For example, the interaction of alpha 2 beta 1 integrin and collagen has been shown to have an important role in thrombus formation and cancer spread. The fact that the discovery of small molecules that can block such protein-protein interactions is highly challenging has significantly hindered the discovery of pharmaceutical agents to treat these diseases. Here, we present a rationally designed novel fluorescent molecule that can be synthesized in just a few minutes from commercially available starting materials. This molecule blocks the protein-protein interaction between alpha 2 beta 1 integrin and collagen, and due to its fluorescent properties, it can be employed in wide variety of biological applications.
Collagen binding integrins are an important family of cell surface receptors that mediate bidirectionally signals between the interior of the cell and the extracellular matrix. The protein-protein interactions between cells and collagen are necessary for many physiological functions, but also promote diseases. For example, the interaction of alpha 2 beta 1 integrin and collagen has been shown to have an important role in thrombus formation and cancer spread. The fact that the discovery of small molecules that can block such protein-protein interactions is highly challenging has significantly hindered the discovery of pharmaceutical agents to treat these diseases. Here, we present a rationally designed novel fluorescent molecule that can be synthesized in just a few minutes from commercially available starting materials. This molecule blocks the protein-protein interaction between alpha 2 beta 1 integrin and collagen, and due to its fluorescent properties, it can be employed in wide variety of biological applications.
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