A1 Refereed original research article in a scientific journal

Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function




AuthorsKoivunen JT, Nissinen L, Kapyla J, Jokinen J, Pihlavisto M, Marjamaki A, Heino J, Huuskonen J, Pentikainen OT

PublisherAMER CHEMICAL SOC

Publication year2011

JournalJournal of the American Chemical Society

Journal name in sourceJOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Journal acronymJ AM CHEM SOC

Number in series37

Volume133

Issue37

First page 14558

Last page14561

Number of pages4

ISSN0002-7863

DOIhttps://doi.org/10.1021/ja206086c(external)


Abstract
Collagen binding integrins are an important family of cell surface receptors that mediate bidirectionally signals between the interior of the cell and the extracellular matrix. The protein-protein interactions between cells and collagen are necessary for many physiological functions, but also promote diseases. For example, the interaction of alpha 2 beta 1 integrin and collagen has been shown to have an important role in thrombus formation and cancer spread. The fact that the discovery of small molecules that can block such protein-protein interactions is highly challenging has significantly hindered the discovery of pharmaceutical agents to treat these diseases. Here, we present a rationally designed novel fluorescent molecule that can be synthesized in just a few minutes from commercially available starting materials. This molecule blocks the protein-protein interaction between alpha 2 beta 1 integrin and collagen, and due to its fluorescent properties, it can be employed in wide variety of biological applications.



Last updated on 2024-26-11 at 12:35