Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27

: Hogel H, Miikkulainen P, Bino L, Jaakkola PM

Publisher: BIOMED CENTRAL LTD

: 2015

: Molecular Cancer

: MOLECULAR CANCER

: MOL CANCER

: ARTN 143

: 14

: 1476-4598

DOI: https://doi.org/10.1186/s12943-015-0410-5

Conclusions: The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 that occurs by attenuating p27S10 phosphorylation.