A1 Refereed original research article in a scientific journal

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27



Authors: Hogel H, Miikkulainen P, Bino L, Jaakkola PM

Publisher: BIOMED CENTRAL LTD

Publication year: 2015

Journal: Molecular Cancer

Journal name in source: MOLECULAR CANCER

Journal acronym: MOL CANCER

Article number: ARTN 143

Volume: 14

Number of pages: 14

ISSN: 1476-4598

DOI: https://doi.org/10.1186/s12943-015-0410-5


Abstract

Conclusions: The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 that occurs by attenuating p27S10 phosphorylation.




Last updated on 2024-26-11 at 11:33