A1 Refereed original research article in a scientific journal

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27




AuthorsHogel H, Miikkulainen P, Bino L, Jaakkola PM

PublisherBIOMED CENTRAL LTD

Publication year2015

JournalMolecular Cancer

Journal name in sourceMOLECULAR CANCER

Journal acronymMOL CANCER

Article numberARTN 143

Volume14

Number of pages14

ISSN1476-4598

DOIhttps://doi.org/10.1186/s12943-015-0410-5


Abstract

Conclusions: The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 that occurs by attenuating p27S10 phosphorylation.




Last updated on 2024-26-11 at 11:33