A1 Refereed original research article in a scientific journal
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
Authors: Hogel H, Miikkulainen P, Bino L, Jaakkola PM
Publisher: BIOMED CENTRAL LTD
Publication year: 2015
Journal: Molecular Cancer
Journal name in source: MOLECULAR CANCER
Journal acronym: MOL CANCER
Article number: ARTN 143
Volume: 14
Number of pages: 14
ISSN: 1476-4598
DOI: https://doi.org/10.1186/s12943-015-0410-5
Abstract
Conclusions: The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 that occurs by attenuating p27S10 phosphorylation.