A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Epigenetic Matters: The Link between Early Nutrition, Microbiome, And Long-term Health Development
Tekijät: Indrio F, Martini S, Francavilla R, Corvaglia L, Cristofori F, Mastrolia SA, Neu J, Rautava S, Spena GR, Raimondi F, Loverro G
Kustantaja: FRONTIERS MEDIA SA
Kustannuspaikka: Lausanne
Julkaisuvuosi: 2017
Journal: Frontiers in Pediatrics
Tietokannassa oleva lehden nimi: FRONTIERS IN PEDIATRICS
Lehden akronyymi: FRONT PEDIATR
Artikkelin numero: ARTN 178
Vuosikerta: 5
Sivujen määrä: 14
ISSN: 2296-2360
eISSN: 2296-2360
DOI: https://doi.org/10.3389/fped.2017.00178
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/26706702
Epigenetic modifications are among the most important mechanisms by which environmental factors can influence early cellular differentiation and create new phenotypic traits during pregnancy and within the neonatal period without altering the deoxyribonucleic acid sequence. A number of antenatal and postnatal factors, such as maternal and neonatal nutrition, pollutant exposure, and the composition of microbiota, contribute to the establishment of epigenetic changes that can not only modulate the individual adaptation to the environment but also have an influence on lifelong health and disease by modifying inflammatory molecular pathways and the immune response. Postnatal intestinal colonization, in turn determined by maternal flora, mode of delivery, early skin-to-skin contact and neonatal diet, leads to specific epigenetic signatures that can affect the barrier properties of gut mucosa and their protective role against later insults, thus potentially predisposing to the development of late-onset inflammatory diseases. The aim of this review is to outline the epigenetic mechanisms of programming and development acting within early-life stages and to examine in detail the role of maternal and neonatal nutrition, microbiota composition, and other environmental factors in determining epigenetic changes and their short-and long-term effects.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
