New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles

: Vale N, Makila E, Salonen J, Gomes P, Hirvonen J, Santos HA

Publisher: ELSEVIER SCIENCE BV

: 2012

: European Journal of Pharmaceutics and Biopharmaceutics

: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

: EUR J PHARM BIOPHARM

: 2

: 81

: 2

: 314

: 323

: 10

: 0939-6411

DOI: https://doi.org/10.1016/j.ejpb.2012.02.017(external)

In addition, new thiolated metabolites were identified from incubation of ETA-loaded PSi with HepG2 liver cells, which opens new perspectives toward both the understanding of ETA metabolism and the development of novel ETA-based systems with improved efficacy against MDR-TB. (C) 2012 Elsevier B.V. All rights reserved.