A1 Refereed original research article in a scientific journal

New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles




AuthorsVale N, Makila E, Salonen J, Gomes P, Hirvonen J, Santos HA

PublisherELSEVIER SCIENCE BV

Publication year2012

JournalEuropean Journal of Pharmaceutics and Biopharmaceutics

Journal name in sourceEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Journal acronymEUR J PHARM BIOPHARM

Number in series2

Volume81

Issue2

First page 314

Last page323

Number of pages10

ISSN0939-6411

DOIhttps://doi.org/10.1016/j.ejpb.2012.02.017


Abstract
In addition, new thiolated metabolites were identified from incubation of ETA-loaded PSi with HepG2 liver cells, which opens new perspectives toward both the understanding of ETA metabolism and the development of novel ETA-based systems with improved efficacy against MDR-TB. (C) 2012 Elsevier B.V. All rights reserved.



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