B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Collagen Turnover in Wound Repair--A Macrophage Connection
Tekijät: Nissinen LM, Kähäri VM
Kustantaja: Nature Publishing Group
Julkaisuvuosi: 2015
Journal: Journal of Investigative Dermatology
Lehden akronyymi: J Invest Dermatol
Vuosikerta: 135
Numero: 10
Aloitussivu: 2350
Lopetussivu: 2352
Sivujen määrä: 3
ISSN: 0022-202X
DOI: https://doi.org/10.1038/jid.2015.246(external)
In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.
