B1 Non-refereed article in a scientific journal
Collagen Turnover in Wound Repair--A Macrophage Connection
Authors: Nissinen LM, Kähäri VM
Publisher: Nature Publishing Group
Publication year: 2015
Journal: Journal of Investigative Dermatology
Journal acronym: J Invest Dermatol
Volume: 135
Issue: 10
First page : 2350
Last page: 2352
Number of pages: 3
ISSN: 0022-202X
DOI: https://doi.org/10.1038/jid.2015.246(external)
In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.
