Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study

: Raiko JRH, Oikonen M, Wendelin-Saarenhovi M, Siitonen N, Kahonen M, Lehtimaki T, Viikari J, Jula A, Loo BM, Huupponen R, Saarikoski L, Juonala M, Raitakari OT

Publisher: ELSEVIER IRELAND LTD

: 2012

: Atherosclerosis

: ATHEROSCLEROSIS

: 1

: 224

: 1

: 208

: 212

: 5

: 0021-9150

DOI: https://doi.org/10.1016/j.atherosclerosis.2012.06.062

Conclusion: PAI-1 was independently associated with several known CVD risk factors, especially obesity markers, in both men and women. However, addition of PAI-1 to known risk factors did not improve cross-sectional prediction of high cIMT, low CDist and low FMD suggesting that PAI-1 is not a clinically important biomarker in early atherosclerosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Internal medicine