A1 Refereed original research article in a scientific journal
Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study
Authors: Raiko JRH, Oikonen M, Wendelin-Saarenhovi M, Siitonen N, Kahonen M, Lehtimaki T, Viikari J, Jula A, Loo BM, Huupponen R, Saarikoski L, Juonala M, Raitakari OT
Publisher: ELSEVIER IRELAND LTD
Publication year: 2012
Journal: Atherosclerosis
Journal name in source: ATHEROSCLEROSIS
Journal acronym: ATHEROSCLEROSIS
Number in series: 1
Volume: 224
Issue: 1
First page : 208
Last page: 212
Number of pages: 5
ISSN: 0021-9150
DOI: https://doi.org/10.1016/j.atherosclerosis.2012.06.062
Abstract
Conclusion: PAI-1 was independently associated with several known CVD risk factors, especially obesity markers, in both men and women. However, addition of PAI-1 to known risk factors did not improve cross-sectional prediction of high cIMT, low CDist and low FMD suggesting that PAI-1 is not a clinically important biomarker in early atherosclerosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Conclusion: PAI-1 was independently associated with several known CVD risk factors, especially obesity markers, in both men and women. However, addition of PAI-1 to known risk factors did not improve cross-sectional prediction of high cIMT, low CDist and low FMD suggesting that PAI-1 is not a clinically important biomarker in early atherosclerosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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