Measurements of [C-11]CO2 in Exhaled Air with a Positron-sensitive Single-wire Proportional Counter after i.v. Injection of [C-11]Acetate



: Sipila HT, Heselius SL, Kalliokoski MK, Kemppainen J, Minn H, Tolvanen T, Roivainen A

: 2011

: IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference

: 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC)

: IEEE NUCL SCI CONF R

: 2397

: 2399

: 3

: 1082-3654


A positron-sensitive, large-window single-wire proportional counter was used for measurements of [C-11]CO2 in exhaled air after i.v. injection of [C-11] acetate. The performance of the proportional counter was studied using Geant4 and Garfield simulation tools as well as experimentally by injections of known amounts of radioactive gas into the measuring volume. The proportional counter was found to be sensitive enough for measuring the low concentrations of [C-11]CO2 in the air exhaled by patients after i.v. injection of an C-11-Iabelled radiopharmaceutical. The limit of detection was 200 Bq/L for [C-11]CO2.



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