G5 Artikkeliväitöskirja
Health and quality of life after young age onset brain tumor
Tekijät: Gunn Erika
Kustantaja: University of Turku
Kustannuspaikka: Turku
Julkaisuvuosi: 2017
ISBN: 978-951-29-6949-4
eISBN: 978-951-29-6950-0
Verkko-osoite: http://urn.fi/URN:ISBN:978-951-29-6950-0
Rinnakkaistallenteen osoite: http://urn.fi/URN:ISBN:978-951-29-6950-0
Tiivistelmä
The survivors of young age onset brain tumors (BT) often experience several late-effects due to their tumor and its treatment, and their quality of life (QOL) may be compromised. The aim of this study was to explore in detail these late-effects and the QOL after diagnosis of young onset BT.
We identified 740 survivors diagnosed with childhood and 315 survivors with adolescence and young adulthood (AYA) BT between 1970 and 2004 from Finnish Cancer Registry. Morbidity emerging at least five years after the BT diagnosis was analyzed based on data from the Hospital Discharge Registry and compared with a sibling control group. Data was analyzed from Social Insurance Institution of Finland concerning neurological and endocrinological drug purchases for 602 young age onset BT survivors diagnosed between 1988 and 2004. The QOL for 21 childhood ependymoma or medulloblastoma survivors was evaluated in a mixed method analysis.
Both childhood and AYA BT survivors had an increased hazard ratio for endocrinological, psychiatric, neurological, and cerebrovascular diseases as well as for disorders of vision and hearing. Survivors also experienced cognitive and developmental disorders. AYA survivors had an increased risk for developing nephrological morbidity. Medications for endocrinological and neurological morbidity were frequently used, and the need for new medication still occurred many years after the BT diagnosis. Several aspects of health-related QOL were impaired in childhood BT survivors. However, there was extensive variability in QOL, with many survivors also relating positive consequences from their cancer. Survivors themselves assessed social relationships as important for their QOL.
Young age onset BT survivors may encounter multiple health related late-effects and are at risk of experiencing social difficulties. For these reasons, it is important that they should be systematically followed up in a health care unit specialized to deal with their adult life needs.
The survivors of young age onset brain tumors (BT) often experience several late-effects due to their tumor and its treatment, and their quality of life (QOL) may be compromised. The aim of this study was to explore in detail these late-effects and the QOL after diagnosis of young onset BT.
We identified 740 survivors diagnosed with childhood and 315 survivors with adolescence and young adulthood (AYA) BT between 1970 and 2004 from Finnish Cancer Registry. Morbidity emerging at least five years after the BT diagnosis was analyzed based on data from the Hospital Discharge Registry and compared with a sibling control group. Data was analyzed from Social Insurance Institution of Finland concerning neurological and endocrinological drug purchases for 602 young age onset BT survivors diagnosed between 1988 and 2004. The QOL for 21 childhood ependymoma or medulloblastoma survivors was evaluated in a mixed method analysis.
Both childhood and AYA BT survivors had an increased hazard ratio for endocrinological, psychiatric, neurological, and cerebrovascular diseases as well as for disorders of vision and hearing. Survivors also experienced cognitive and developmental disorders. AYA survivors had an increased risk for developing nephrological morbidity. Medications for endocrinological and neurological morbidity were frequently used, and the need for new medication still occurred many years after the BT diagnosis. Several aspects of health-related QOL were impaired in childhood BT survivors. However, there was extensive variability in QOL, with many survivors also relating positive consequences from their cancer. Survivors themselves assessed social relationships as important for their QOL.
Young age onset BT survivors may encounter multiple health related late-effects and are at risk of experiencing social difficulties. For these reasons, it is important that they should be systematically followed up in a health care unit specialized to deal with their adult life needs.
Turun yliopiston Tutkimustietojärjestelmän portaali