ss(LG) values in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification

: Heidi Korhonen, Nicholas H Williams, Satu Mikkola

Publisher: WILEY-BLACKWELL

: 2013

: Journal of Physical Organic Chemistry

: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

: J PHYS ORG CHEM

: 2

: 26

: 2

: 182

: 186

: 5

: 0894-3230

DOI: https://doi.org/10.1002/poc.2942(external)

Studies on the mechanism of transesterification reactions of nucleoside 3'-phosphoesters using beta LG values as a mechanistic tool are discussed in this mini review. Our recent observation that a dinuclear metal ion complex enhances both the cleavage and isomerisation is discussed in the light of previous studies. Copyright (C) 2012 John Wiley & Sons, Ltd.