A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa
Vaccination Expectations in HNSCC
Tekijät: Syrjanen Stina, Rautava Jaana
Toimittaja: Wojciech Golusiński, C. René Leemans, Andreas Dietz
Kustantaja: SPRINGER INT PUBLISHING AG, GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
Julkaisuvuosi: 2017
Journal: Recent Results in Cancer Research
Kokoomateoksen nimi: HPV Infection in Head and Neck Cancer
Tietokannassa oleva lehden nimi: HPV INFECTION IN HEAD AND NECK CANCER
Lehden akronyymi: RECENT RESULTS CANC
Sarjan nimi: Recent Results in Cancer Research
Vuosikerta: 206
Aloitussivu: 257
Lopetussivu: 267
Sivujen määrä: 11
ISBN: 978-3-319-43578-7
eISBN: 978-3-319-43580-0
ISSN: 0080-0015
DOI: https://doi.org/10.1007/978-3-319-43580-0_21
Tiivistelmä
HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially effective also against HNSCC. However, before specific results on HNSCC are available, one must keep in mind that carcinogenesis in the head and neck region may differ from that of the anogenital tract. Furthermore, the current evidence supports the view that HPV infection is much more complex than simply a sexually transmitted disease. HPV is present in the semen, placenta and in the newborns, and these infections of the newborns create cell-mediated immunity (CMI) against HPV, including the T memory cells. Acquisition of HPV infection in early life will rise new series of questions in the field of HPV vaccination.
HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially effective also against HNSCC. However, before specific results on HNSCC are available, one must keep in mind that carcinogenesis in the head and neck region may differ from that of the anogenital tract. Furthermore, the current evidence supports the view that HPV infection is much more complex than simply a sexually transmitted disease. HPV is present in the semen, placenta and in the newborns, and these infections of the newborns create cell-mediated immunity (CMI) against HPV, including the T memory cells. Acquisition of HPV infection in early life will rise new series of questions in the field of HPV vaccination.
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