A3 Refereed book chapter or chapter in a compilation book
Vaccination Expectations in HNSCC
Authors: Syrjanen Stina, Rautava Jaana
Editors: Wojciech Golusiński, C. René Leemans, Andreas Dietz
Publisher: SPRINGER INT PUBLISHING AG, GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
Publication year: 2017
Journal: Recent Results in Cancer Research
Book title : HPV Infection in Head and Neck Cancer
Journal name in source: HPV INFECTION IN HEAD AND NECK CANCER
Journal acronym: RECENT RESULTS CANC
Series title: Recent Results in Cancer Research
Volume: 206
First page : 257
Last page: 267
Number of pages: 11
ISBN: 978-3-319-43578-7
eISBN: 978-3-319-43580-0
ISSN: 0080-0015
DOI: https://doi.org/10.1007/978-3-319-43580-0_21
Abstract
HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially effective also against HNSCC. However, before specific results on HNSCC are available, one must keep in mind that carcinogenesis in the head and neck region may differ from that of the anogenital tract. Furthermore, the current evidence supports the view that HPV infection is much more complex than simply a sexually transmitted disease. HPV is present in the semen, placenta and in the newborns, and these infections of the newborns create cell-mediated immunity (CMI) against HPV, including the T memory cells. Acquisition of HPV infection in early life will rise new series of questions in the field of HPV vaccination.
HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially effective also against HNSCC. However, before specific results on HNSCC are available, one must keep in mind that carcinogenesis in the head and neck region may differ from that of the anogenital tract. Furthermore, the current evidence supports the view that HPV infection is much more complex than simply a sexually transmitted disease. HPV is present in the semen, placenta and in the newborns, and these infections of the newborns create cell-mediated immunity (CMI) against HPV, including the T memory cells. Acquisition of HPV infection in early life will rise new series of questions in the field of HPV vaccination.
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