A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Striatal FDOPA uptake and cognition in advanced non-demented Parkinson's disease: A clinical and FDOPA-PET study
Tekijät: van Beilen M, Portman AT, Kiers HAL, Maguire RP, Kaasinen V, Koning M, Pruim J, Leenders KL
Kustantaja: ELSEVIER SCI LTD
Julkaisuvuosi: 2008
Journal: Parkinsonism and Related Disorders
Tietokannassa oleva lehden nimi: PARKINSONISM & RELATED DISORDERS
Lehden akronyymi: PARKINSONISM RELAT D
Vuosikerta: 14
Numero: 3
Aloitussivu: 224
Lopetussivu: 228
Sivujen määrä: 5
ISSN: 1353-8020
DOI: https://doi.org/10.1016/j.parkreldis.2007.08.011
Tiivistelmä
This study sought to determine the nature of the relationship between cognition and striatal dopaminergic functioning in 28 patients with advanced Parkinson's disease (PD) using fluorodopa Positron emission tomography (FDOPA-PET) and neuropsychological test scores. Mental flexibility was related to putamen activity while metal organization (executive memory and fluency) was related to caudate FDOPA uptake. Interestingly, the caudate may be more important in the mental components of executive functioning, while the putamen may be more important in the motor components of executive functioning. (c) 2007 Elsevier Ltd. All rights reserved.
This study sought to determine the nature of the relationship between cognition and striatal dopaminergic functioning in 28 patients with advanced Parkinson's disease (PD) using fluorodopa Positron emission tomography (FDOPA-PET) and neuropsychological test scores. Mental flexibility was related to putamen activity while metal organization (executive memory and fluency) was related to caudate FDOPA uptake. Interestingly, the caudate may be more important in the mental components of executive functioning, while the putamen may be more important in the motor components of executive functioning. (c) 2007 Elsevier Ltd. All rights reserved.
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