A1 Refereed original research article in a scientific journal
Striatal FDOPA uptake and cognition in advanced non-demented Parkinson's disease: A clinical and FDOPA-PET study
Authors: van Beilen M, Portman AT, Kiers HAL, Maguire RP, Kaasinen V, Koning M, Pruim J, Leenders KL
Publisher: ELSEVIER SCI LTD
Publication year: 2008
Journal: Parkinsonism and Related Disorders
Journal name in source: PARKINSONISM & RELATED DISORDERS
Journal acronym: PARKINSONISM RELAT D
Volume: 14
Issue: 3
First page : 224
Last page: 228
Number of pages: 5
ISSN: 1353-8020
DOI: https://doi.org/10.1016/j.parkreldis.2007.08.011
Abstract
This study sought to determine the nature of the relationship between cognition and striatal dopaminergic functioning in 28 patients with advanced Parkinson's disease (PD) using fluorodopa Positron emission tomography (FDOPA-PET) and neuropsychological test scores. Mental flexibility was related to putamen activity while metal organization (executive memory and fluency) was related to caudate FDOPA uptake. Interestingly, the caudate may be more important in the mental components of executive functioning, while the putamen may be more important in the motor components of executive functioning. (c) 2007 Elsevier Ltd. All rights reserved.
This study sought to determine the nature of the relationship between cognition and striatal dopaminergic functioning in 28 patients with advanced Parkinson's disease (PD) using fluorodopa Positron emission tomography (FDOPA-PET) and neuropsychological test scores. Mental flexibility was related to putamen activity while metal organization (executive memory and fluency) was related to caudate FDOPA uptake. Interestingly, the caudate may be more important in the mental components of executive functioning, while the putamen may be more important in the motor components of executive functioning. (c) 2007 Elsevier Ltd. All rights reserved.
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