A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Brain Structure and Organization Five Decades After Childhood Onset Epilepsy
Tekijät: Garcia-Ramos C, Bobholz S, Dabbs K, Hermann B, Joutsa J, Rinne JO, Karrasch M, Prabhakaran V, Shinnar S, Sillanpää M
Kustantaja: WILEY
Julkaisuvuosi: 2017
Journal: Human Brain Mapping
Tietokannassa oleva lehden nimi: HUMAN BRAIN MAPPING
Lehden akronyymi: HUM BRAIN MAPP
Vuosikerta: 38
Numero: 6
Aloitussivu: 3289
Lopetussivu: 3299
Sivujen määrä: 11
ISSN: 1065-9471
DOI: https://doi.org/10.1002/hbm.23593
Verkko-osoite: https://research.utu.fi/converis/portal/Publication/25704792
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/25704792
The purpose of this project was to characterize brain structure and organization in persons with active and remitted childhood onset epilepsy 50 years after diagnosis compared with healthy controls. Participants from a population-based investigation of uncomplicated childhood onset epilepsy were followed up 5 decades later. Forty-one participants had a history of childhood onset epilepsy (mean age of onset=5.2 years, current chronological age=56.0 years) and were compared with 48 population-based controls (mean age=55.9 years). Of the epilepsy participants, 8 had persisting active epilepsy and in 33 the epilepsy had remitted. All participants underwent 3T MRI with subsequent vertex analysis of cortical volume, thickness, surface area and gyral complexity. In addition, cortical and subcortical volumes, including regions of the frontal, parietal, temporal, and occipital lobes, and subcortical structures including amygdala, thalamus, and hippocampus, were analyzed using graph theory techniques. There were modest group differences in traditional vertex-based analyses of cortical volume, thickness, surface area and gyral index, as well as across volumes of subcortical structures, after correction for multiple comparisons. Graph theory analyses revealed suboptimal topological structural organization with enhanced network segregation and reduced global integration in the epilepsy participants compared with controls, these patterns significantly more extreme in the active epilepsy group. Furthermore, both groups with epilepsy presented a greater number of higher Z-score regions in betweenness centrality (BC) than lower Z-score regions compared with controls. Also, contrary to the group with remitted epilepsy, patients with active epilepsy presented most of their high BC Z-score regions in subcortical areas including the amygdala, thalamus, hippocampus, pallidum, and accumbens. Overall, this population-based investigation of long term outcome (5 decades) of childhood onset epilepsy reveals persisting abnormalities, especially when examined by graph theoretical measurements, and provides new insights into the very long-term outcomes of active and remitted epilepsy. (C) 2017 Wiley Periodicals, Inc.
Ladattava julkaisu This is an electronic reprint of the original article. |   | |
Ladattava julkaisu This is an electronic reprint of the original article. |  | |
Ladattava julkaisu This is an electronic reprint of the original article. | ||
Ladattava julkaisu This is an electronic reprint of the original article. | | |
Ladattava julkaisu This is an electronic reprint of the original article. |  | |
Ladattava julkaisu This is an electronic reprint of the original article. |  | |
Ladattava julkaisu This is an electronic reprint of the original article. |  | |
Ladattava julkaisu This is an electronic reprint of the original article. | | |
Ladattava julkaisu This is an electronic reprint of the original article. |  |
