Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life



: Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT

Publisher: MOSBY, INC

: 2006

: Clinical Pharmacology and Therapeutics

: CLINICAL PHARMACOLOGY & THERAPEUTICS

: CLIN PHARMACOL THER

: 80

: 5

: 502

: 508

: 7

: 0009-9236

DOI: https://doi.org/10.1016/j.clpt.2006.07.008


Conclusion: Oral voriconazole, but not terbinafine, markedly inhibited the metabolism of alfentanil. Caution should be exercised when alfentanil is given to patients receiving voriconazole. It is reasonable to assume that patients receiving voriconazole require 70% to 90% less alfentanil for the maintenance of analgesia than patients who are not receiving concomitant CYP3A inhibitors.



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