A1 Refereed original research article in a scientific journal
Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life
Authors: Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT
Publisher: MOSBY, INC
Publication year: 2006
Journal: Clinical Pharmacology and Therapeutics
Journal name in source: CLINICAL PHARMACOLOGY & THERAPEUTICS
Journal acronym: CLIN PHARMACOL THER
Volume: 80
Issue: 5
First page : 502
Last page: 508
Number of pages: 7
ISSN: 0009-9236
DOI: https://doi.org/10.1016/j.clpt.2006.07.008
Abstract
Conclusion: Oral voriconazole, but not terbinafine, markedly inhibited the metabolism of alfentanil. Caution should be exercised when alfentanil is given to patients receiving voriconazole. It is reasonable to assume that patients receiving voriconazole require 70% to 90% less alfentanil for the maintenance of analgesia than patients who are not receiving concomitant CYP3A inhibitors.
Conclusion: Oral voriconazole, but not terbinafine, markedly inhibited the metabolism of alfentanil. Caution should be exercised when alfentanil is given to patients receiving voriconazole. It is reasonable to assume that patients receiving voriconazole require 70% to 90% less alfentanil for the maintenance of analgesia than patients who are not receiving concomitant CYP3A inhibitors.
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