Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine



: Hagelberg NM, Peltoniemi MA, Saari TI, Kurkinen KJ, Laine K, Neuvonen PJ, Olkkola KT

Publisher: ELSEVIER SCI LTD

: 2010

: European Journal of Pain

: EUROPEAN JOURNAL OF PAIN

: EUR J PAIN

: 6

: 14

: 6

: 625

: 629

: 5

: 1090-3801

DOI: https://doi.org/10.1016/j.ejpain.2009.10.003


Conclusions: Clarithromycin strongly increases plasma concentrations of oral S-ketamine probably by inhibiting its CYP3A-mediated N-demethylation. This increase is reflected as modest changes in behavioral effects of oral S-ketamine. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.



Last updated on 2024-26-11 at 12:16