A1 Refereed original research article in a scientific journal

Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine



Authors: Hagelberg NM, Peltoniemi MA, Saari TI, Kurkinen KJ, Laine K, Neuvonen PJ, Olkkola KT

Publisher: ELSEVIER SCI LTD

Publication year: 2010

Journal: European Journal of Pain

Journal name in source: EUROPEAN JOURNAL OF PAIN

Journal acronym: EUR J PAIN

Number in series: 6

Volume: 14

Issue: 6

First page : 625

Last page: 629

Number of pages: 5

ISSN: 1090-3801

DOI: https://doi.org/10.1016/j.ejpain.2009.10.003


Abstract
Conclusions: Clarithromycin strongly increases plasma concentrations of oral S-ketamine probably by inhibiting its CYP3A-mediated N-demethylation. This increase is reflected as modest changes in behavioral effects of oral S-ketamine. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.



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