A1 Refereed original research article in a scientific journal
Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine
Authors: Hagelberg NM, Peltoniemi MA, Saari TI, Kurkinen KJ, Laine K, Neuvonen PJ, Olkkola KT
Publisher: ELSEVIER SCI LTD
Publication year: 2010
Journal:European Journal of Pain
Journal name in sourceEUROPEAN JOURNAL OF PAIN
Journal acronym: EUR J PAIN
Number in series: 6
Volume: 14
Issue: 6
First page : 625
Last page: 629
Number of pages: 5
ISSN: 1090-3801
DOI: https://doi.org/10.1016/j.ejpain.2009.10.003
Abstract
Conclusions: Clarithromycin strongly increases plasma concentrations of oral S-ketamine probably by inhibiting its CYP3A-mediated N-demethylation. This increase is reflected as modest changes in behavioral effects of oral S-ketamine. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
Conclusions: Clarithromycin strongly increases plasma concentrations of oral S-ketamine probably by inhibiting its CYP3A-mediated N-demethylation. This increase is reflected as modest changes in behavioral effects of oral S-ketamine. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
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