A1 Refereed original research article in a scientific journal
Galactoglucomannan-rich hemicellulose extract from Norway spruce (Picea abies) exerts beneficial effects on chronic prostatic inflammation and lower urinary tract symptoms in vivo
Authors: Konkol Y, Vuorikoski H, Tuomela J, Holmbom B, Bernoulli J
Publisher: ELSEVIER SCIENCE BV
Publication year: 2017
Journal: International Journal of Biological Macromolecules
Journal name in source: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Journal acronym: INT J BIOL MACROMOL
Volume: 101
First page : 222
Last page: 229
Number of pages: 8
ISSN: 0141-8130
eISSN: 1879-0003
DOI: https://doi.org/10.1016/j.ijbiomac.2017.03.079
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/25299888
Galactoglucomannan (GGM) is the main hemicellulose class in wood of coniferous trees and could be potentially utilized as a possible health-promoting substance for food and pharmaceutical industry. Our aim was to evaluate effects of orally administered GGM-rich extract from Norway spruce in a rat model of chronic prostatitis associated with lower urinary tract symptoms (LUTS). Prostatic inflammation and LUTS was induced in male rats using testosterone and 17 beta-estradiol exposure for 18 weeks. Rats were treated with 2% GGM dissolved in drinking water during weeks 13-18. Pelvic pain response, LUT function and histopathological evaluation of the prostate were assessed. The results show that hormonal exposure induced LUTS seen as decreased urine flow rate, increased bladder pressure, voiding times, bladder capacity and residual urine volumes. GGM had positive effects on urodynamical parameters by decreasing the basal bladder pressure, increasing the urine flow rate and volume, reducing the residual volume and increasing micturition intervals. GGM reduced the extent of the hormone exposure-induced prostatic inflammation. Increase of pelvic pain induced by hormone exposure was only slightly affected by GGM treatment. The results suggest that orally administered GGM may have potential usage for improving lower urinary tract function associated with chronic prostatic inflammation. (C) 2017 Elsevier B.V. All rights reserved.
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