A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction
Tekijät: Hagelberg NM, Saarikoski T, Saari TI, Neuvonen M, Neuvonen PJ, Turpeinen M, Scheinin M, Laine K, Olkkola KT
Kustantaja: SPRINGER HEIDELBERG
Julkaisuvuosi: 2013
Journal: European Journal of Clinical Pharmacology
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Lehden akronyymi: EUR J CLIN PHARMACOL
Numero sarjassa: 4
Vuosikerta: 69
Numero: 4
Aloitussivu: 867
Lopetussivu: 875
Sivujen määrä: 9
ISSN: 0031-6970
DOI: https://doi.org/10.1007/s00228-012-1433-0
Tiivistelmä
Ticlopidine increased exposure to tramadol, reduced its renal clearance and inhibited the formation of M1, most likely via inhibition of CYP2B6 and/or CYP2D6. The addition of itraconazole to ticlopidine did not modify the outcome of the drug interaction. Concomitant clinical use of ticlopidine and tramadol may enhance the risk of serotonergic effects, especially when higher doses of tramadol are used.
Ticlopidine increased exposure to tramadol, reduced its renal clearance and inhibited the formation of M1, most likely via inhibition of CYP2B6 and/or CYP2D6. The addition of itraconazole to ticlopidine did not modify the outcome of the drug interaction. Concomitant clinical use of ticlopidine and tramadol may enhance the risk of serotonergic effects, especially when higher doses of tramadol are used.
Turun yliopiston Tutkimustietojärjestelmän portaali