A1 Refereed original research article in a scientific journal
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction
Authors: Hagelberg NM, Saarikoski T, Saari TI, Neuvonen M, Neuvonen PJ, Turpeinen M, Scheinin M, Laine K, Olkkola KT
Publisher: SPRINGER HEIDELBERG
Publication year: 2013
Journal: European Journal of Clinical Pharmacology
Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Journal acronym: EUR J CLIN PHARMACOL
Number in series: 4
Volume: 69
Issue: 4
First page : 867
Last page: 875
Number of pages: 9
ISSN: 0031-6970
DOI: https://doi.org/10.1007/s00228-012-1433-0
Abstract
Ticlopidine increased exposure to tramadol, reduced its renal clearance and inhibited the formation of M1, most likely via inhibition of CYP2B6 and/or CYP2D6. The addition of itraconazole to ticlopidine did not modify the outcome of the drug interaction. Concomitant clinical use of ticlopidine and tramadol may enhance the risk of serotonergic effects, especially when higher doses of tramadol are used.
Ticlopidine increased exposure to tramadol, reduced its renal clearance and inhibited the formation of M1, most likely via inhibition of CYP2B6 and/or CYP2D6. The addition of itraconazole to ticlopidine did not modify the outcome of the drug interaction. Concomitant clinical use of ticlopidine and tramadol may enhance the risk of serotonergic effects, especially when higher doses of tramadol are used.
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